Now, he is joining Marrone again.
But, this time, he is doing it in the professional ranks for the Buffalo Bills.
Hackett will reprise his role as Marrone's offensive coordinator, rising to a new level in his personal history in the NFL.
He had previously been a member of the Bills' staff as a quality-control coach from 2008-09, doing the same job for the NFL's Tampa Bay Buccaneers before that, from 2006-07.
Looking back to his time at Syracuse, with Ryan Nassib beginning the 2010 season as Syracuse's starting quarterback for the first time, Hackett helped lead Nassib into the school's top-10 in completions, completion percentage, passing yards, and passing touchdowns.
Nassib and the Orange offense helped the Orange to a 7-5 regular season record and hung tough in their first trip to the New Era Pinstripe Bowl to win a competitive offensive battle versus the Kansas State Wildcats, 36-34.
In his second season, Hackett continued to coach the quarterbacks and tight ends, but also rose to the position of offensive coordinator.
Under Hackett, Syracuse produced a record-setting quarterback and tight end tandem. Nassib set a new bar for the most completions and passing yards, while tying for most passing touchdowns by an Orange quarterback within one season. Tight end Nick Provo spent his final season with Syracuse gaining the most catches by a tight end in the school's history both within a single season and for a career.
Hackett kept the Orange moving in a positive direction in 2012, overseeing Nassib setting new records in career passing yards per game, passing yards, completions, and attempts.
Even more telling of the evolution of Hackett was his appreciation and respect for the running game. Being a pass-happy coordinator, Hackett still understood the importance of a balanced attack.
With Hackett as offensive coordinator, Syracuse has produced a 1,000-yard rusher in each of the last two seasons.
Hackett has most recently instituted a no-huddle offense for Syracuse's 2012 season, which helped to lead the Orange to a 8-5 record, including a 24-point win versus the West Virginia Mountaineers in the New Era Pinstripe Bowl, 38-14.
This style of offense is similar to what the Bills utilized, which has been referred to as the "K-Gun". The role of the "K-Gun" is to give the offense an advantage over an opposing defense by shortening the defense's time to see and react to the offense.